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Monday, April 27, 2020 | History

3 edition of Homing Mechanisms and Cellular Targeting (Advances in Molecular and Cell Biology) found in the catalog.

Homing Mechanisms and Cellular Targeting (Advances in Molecular and Cell Biology)

  • 91 Want to read
  • 18 Currently reading

Published by Elsevier Science .
Written in English

    Subjects:
  • Cellular biology,
  • Molecular biology,
  • Science/Mathematics,
  • Science,
  • Medical,
  • Life Sciences - Biology - Molecular Biology,
  • Science / Molecular Biology,
  • Life Sciences - Cytology

  • The Physical Object
    FormatHardcover
    Number of Pages316
    ID Numbers
    Open LibraryOL9584533M
    ISBN 10155938686X
    ISBN 109781559386869

      Moreover, nuclear targeting of some Aux/IAA proteins has been demonstrated; some are very low in abundance; and some have half-lives of 5 to 10 min. All of these features suggest that at least some of the Aux/IAA proteins are involved in controlling transcription (Guilfoyle, ). Where and how they may function, however, are less clear. homing into the BM of immune deficient mice, demonstrating dynamic regulation of CXCR4 in these cells. AML cells secrete high levels of the proteolytic enzyme elastase. Specific inhibition of elastase reduced in vitro migration, proliferation and in vivo homing of cells from AML patients, in . She was on the Board of Directors of the Foundation in for the Accreditation of Cellular Therapy (FACT) from and in became the President Elect of FACT. Additionally, Dr Bollard was a member of the Cellular, Tissues and Gene Therapies Advisory Committee of the Food and Drug Administration (FDA) from Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem.


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Homing Mechanisms and Cellular Targeting (Advances in Molecular and Cell Biology) by B.R. Zetter Download PDF EPUB FB2

Search in this book series. Homing Mechanisms and Cellular Targeting. Edited by E. Edward Bittar, Bruce R. Zetter. Volume 9, Pages iii-xii, () Download full volume. Previous Homing Mechanisms and Cellular Targeting book. Next volume. Actions for selected chapters. Select all / Deselect all.

Download PDFs Export citations. Get this from a library. Homing mechanisms and cellular targeting. [E Edward Bittar; Bruce R Zetter;] -- While some cells divide, live, and die all in the same tissue locale, others travel freely throughout the body, originating in one site and taking up residence at another.

Many of these cells are. Herein, we provide a concise review of active and passive MSC homing mechanisms and biodistribution postinfusion; in addition to in vivo cell tracking methodologies and strategies to enhance tumor targeting with a focus on MSC‐based drug delivery strategies for cancer therapy.

S tem C ells T ranslational M edicine ;1– In this serie we hope to capture some of the excitement and vitality that characterizes the state of Molecular and Cell Biology today. We have chosen an approach in which individual researchers at the forefront of cell biology have been invited to highlight some of the most important research and technical advances in their research.

This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases.

StemBook in conversation with Joanne Kurtzberg about cord blood transplantation, cerebral palsy, and metabolic diseases Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation. marrow and their splenic targeting.

Determine the mechanisms regulating immature B cell differentiation in the spleen. Regulation of immature B cells egress from the BM and their splenic targeting: B-cell development involves the ordered progression of a stem cell through a number of stages, ultimately resulting in a mature B cell.

Butcher E.C. () Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting. In: Gupta S., Waldmann T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol Springer, Boston, MACited by: The mechanisms by which a drug delivery system is targeted are mainly divided into two types: passive targeting and active targeting.

Passive Homing Mechanisms and Cellular Targeting book. Passive Homing Mechanisms and Cellular Targeting book is a mechanism by which the pathological conditions of the target can be utilized to allow for the preferential accumulation of Cited by: 1.

Majors Cellular Biology. This note Homing Mechanisms and Cellular Targeting book designed to introduce students to the principals of cellular and molecular biology, genetics, and evolution.

It is intended for biology majors intending to take more advanced courses later in their academic careers. Emphasis is on cellular structure and function, metabolism, and replication. Review Chapters. Cellular and nuclear reprogramming.

Inducing pluripotency. Mechanisms regulating stem cell polarity and the specification of asymmetric divisions D. Leanne Jones. Stem cell immunology. Immunologic targeting of the cancer stem cell. Catherine J. Immunological considerations for cell therapy using human embryonic stem. Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge.

This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Homing Mechanisms and Cellular Targeting book Regulatory Mechanisms, and Cellular Basis of Disease and Therapy.

Author(s): Stevo Najman. Abstract. How does the pattern of the rudiments of the major blood vessels establish itself in the developing embryo. To understand the cellular biology of these events we must know how the angioblasts, the precursors of endothelial cells, segregate from the mesoderm, migrate, and cohere to one another to Homing Mechanisms and Cellular Targeting book the cords and tubes which are the earliest embryonic blood by: 1.

While significant information is known about lymphocyte homing to the small intestine, skin and lymph nodes [39,40] and a number of lymphocyte homing receptors have been identified, including.

Irene Ghobrial, MD - Medical Oncology. Ghobrial received her MD in from Cairo University School of Medicine, Egypt. She completed her Internal Medicine training at Wayne State University, Mich., and her Hematology/Oncology subspecialty training at Mayo Clinic College of Medicine, Minn.

She joined Dana-Farber in the field of Wa. In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine.

cellular, and/or tissue damage. The strategies for gene modiÞ cation are currently numerous and diverse and are sub-jected to continuous evolution, improvement, and optimization. This book brings together many experts in the Þ eld of gene correction to disclose a wide and varied array of speciÞ cFile Size: 8MB.

Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and the need for the administration of repetitive doses.

In the last decade, one of the main foci in NMDD has been the realization of NP-mediated drug Cited by: 1. Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology.

Over recent decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies—a grim condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to achieve elevated local concentration and extended half-life of the drugs in the peritoneal cavity to improve their anticancer by: 6.

Bone is the preferred target of neoplasms such as prostate, breast, lung and melanoma cancers. Disseminated tumor cells (DTCs) from these cancers take advantage of the protective bone marrow niche normally occupied by hematopoietic stem cells (HSCs) and home to this space in a multistep process involving a variety of chemokines, adhesion molecules and physical : Alexandra E.

Forest, Yusuke Shiozawa, Kenneth J. Pienta, Russell S. Taichman. The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models.

Targeting PC Homing and Survival. A number of recent efforts have been made to target certain factors involved in PC homing/migration or interfere with their survival in order to affect long-lived PCs otherwise refractory to treatment (reviewed recently 2), including autologous stem cell transplantation.

97 Clinical experiences are very limited Cited by: Get this from a library. Homing endonucleases and inteins. [Marlene Belfort;] -- This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and.

Tumor metastasis research examines the mechanisms that allow cancer cells to leave the primary tumor and spread to another part of the body. Learn about recent tumor metastasis research studies supported by the Division of Cancer Biology.

Our current research focuses on novel mechanisms/cellular signaling of GSC biology, tumorigenesis, progression, invasion/metastasis, angiogenesis and therapy responses of GSCs and GBMs. MicroRNAs (miRs) and non-coding RNAs in GSCs and GBMs – miRs and other small non-coding RNAs act as transcription repressors or inducers of gene expression.

We investigated the mechanism by which transferrin-coated gold nanoparticles (Au NP) of different sizes and shapes entered mammalian cells. We determined that transferrin-coated Au NP entered the cells via clathrin-mediated endocytosis pathway.

The NPs exocytosed out of the cells in a linear relationship to size. This was different than the relationship between uptake and by: Title: Targeting Hypoxia Inducible Factor-1&#;: A Novel Mechanism of Ginsenoside Rg1 for Brain Repair after Hypoxia/Ischemia Brain Damage VOLUME: 10 ISSUE: 2 Author(s):Binzhi Tang, Yi Qu, Dejian Wang and Dezhi Mu Affiliation:Department of Pediatrics, West China Second University Hospital, Sichuan University, China.

Keywords:Angiogenesis, cell survival, cellular signal pathway, ginsenoside Cited by: The present work suggests the following insights into the mechanisms regulating the membrane-association of Rab GTPases: 1) di-geranylgeranylation is required for targeting and function of Rab5a and Rab27a to endosomes and melanosomes, respectively, because mono-geranylgeranylated mutants are mistargeted to ER membranes and are unable to.

Regulation of cell-trafficking in hematologic malignancies: Translating cellular mechanisms to therapeutic applications induces egress of tumor cells from the BM and enhances homing of circulating cells to new BM niches.

Targeting cell trafficking-regulating proteins (chemokines receptors, adhesion molecules and downstream signaling) and. Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress made over the past decade in cancer medicine our understanding of Cited by: The number of novel therapies for the treatment of multiple myeloma (MM) is rapidly increasing with proteasome inhibitors, immunomodulatory agents and monoclonal antibodies being the most well-known therapeutic classes whilst histone deacetylase inhibitors, selective inhibitors of nuclear export and CAR-T cells amongst others also being actively investigated.

However, in parallel with the Author: Craig T. Wallington-Beddoe, Douglas W. Coghlan. Metastasis to distant organs and particularly the brain still represents the most serious obstacle in melanoma therapies. Melanoma cells acquire a phenotype to metastasize to the brain and successfully grow there through complex mechanisms determined by microenvironmental than rather genetic cues.

There do appear to be some prerequisites, including the presence of oncogenic BRAF Cited by: 6. Over the past several years, employment of multifunctional polymeric excipients-based nanoparticles for controlled and targeted drug delivery of therapeutic modalities to mucosal membrane-based organelles and systemic circulation has gained enormous interest.

Because they promise to resolve numerous key therapeutical issues associated with current clinical practice including low treatment Author: Maria Hassan Kiani, Masoom Yasinzai, Gul Shahnaz.

Epigenome editing or Epigenome engineering is a type of genetic engineering in which the epigenome is modified at specific sites using engineered molecules targeted to those sites (as opposed to whole-genome modifications). Whereas gene editing involves changing the actual DNA sequence itself, epigenetic editing involves modifying and presenting DNA sequences to proteins and other DNA.

Ensembl ENSG ENSMUSG UniProt P P RefSeq (mRNA) NM_ NM_ NM_ NM_ NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ NP_ NP_ NP_ NP_ Location (UCSC) Chr 2: – Mb Chr 1: Aliases: CXCR4, CD, D2SE, FB22, HM89. This chapter discusses the chief mechanisms of adaptive immunity in mucosal tissues with particular emphasis on the gut, the best understood of the mucosal immune organs.

It describes the organization and main components of the mucosal immune system and the adaptive host defense mechanisms that prevent microbial infection. It also gives schematic representation of the organizational structure Cited by: 5.

Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis Ye Ji Ahn1,2, Tae Hoon Kong1,2, Jin Sil Choi1,2, Wan Su Yun,3 Jaehong Key,3 Young Joon Seo1,21Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, South Korea; 2Department of Otorhinolaryngology, Yonsei University Wonju Cited by: 1.

Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment.

For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that are most vulnerable to reactive oxygen species (ROS).Cited by: Start studying Chapter Regulation of Gene Expression.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Inheritance of traits transmitted by mechanisms not directly involving the nucleotide sequence of a genome These siRNAs associate with a complex of proteins and act as a homing device, targeting the.

Natural killer (NK) pdf are powerful immune effectors whose antitumor activity is regulated pdf a sophisticated network of activating and inhibitory receptors. As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular by: Book Reviews; Editorials; MBoC 20th Anniversary Favorites; MBoC Perspectives on Cell Biology and Human Health; MBoC Technical Perspectives; Meeting Reviews; Obituaries; Perspectives and Essays; Resources; Retrospectives; MBoC Career Perspectives; Collections.

Selected MBoC Articles on Stem Cells; ASCB Resources. ASCB Career Resources; CBE Cited by: At each step of this process, proteins and small molecules provide essential signals. Identifying these signals ebook thus a fundamental goal of regenerative medicine.

Furthermore, treatment with proteins and small molecules in vivo may directly activate repair mechanisms and open an avenue to regenerative medicine without cellular by: